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r, s-sulforaphane (sfn)  (LKT Laboratories)


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    LKT Laboratories r, s-sulforaphane (sfn)
    R, S Sulforaphane (Sfn), supplied by LKT Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/r, s-sulforaphane (sfn)/product/LKT Laboratories
    Average 90 stars, based on 1 article reviews
    r, s-sulforaphane (sfn) - by Bioz Stars, 2026-02
    90/100 stars

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    <t>SFN</t> protects against <t>LPS-induced</t> acute liver injury. (A) Schematic diagram of the experimental design. (B,C) Plasma ALT and AST detection of control and LPS-treated mice with or without SFN pretreatment. (D,E) Representative images of HE staining and TUNEL staining in liver tissues from different groups (D) , and quantitative analysis of TUNEL positive cells (E) . Scale bar, 10 μm, 20x magnification. Five unique and representative fields from each sample were selected for further analysis. Data are presented as mean ± SEM of biologically independent samples. *P < 0.05, **P < 0.01. n = 6 per group. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.
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    <t>SFN</t> protects against <t>LPS-induced</t> acute liver injury. (A) Schematic diagram of the experimental design. (B,C) Plasma ALT and AST detection of control and LPS-treated mice with or without SFN pretreatment. (D,E) Representative images of HE staining and TUNEL staining in liver tissues from different groups (D) , and quantitative analysis of TUNEL positive cells (E) . Scale bar, 10 μm, 20x magnification. Five unique and representative fields from each sample were selected for further analysis. Data are presented as mean ± SEM of biologically independent samples. *P < 0.05, **P < 0.01. n = 6 per group. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.
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    r, s-sulforaphane (sfn)  (LKT Laboratories)
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    <t>SFN</t> protects against <t>LPS-induced</t> acute liver injury. (A) Schematic diagram of the experimental design. (B,C) Plasma ALT and AST detection of control and LPS-treated mice with or without SFN pretreatment. (D,E) Representative images of HE staining and TUNEL staining in liver tissues from different groups (D) , and quantitative analysis of TUNEL positive cells (E) . Scale bar, 10 μm, 20x magnification. Five unique and representative fields from each sample were selected for further analysis. Data are presented as mean ± SEM of biologically independent samples. *P < 0.05, **P < 0.01. n = 6 per group. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.
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    Image Search Results


    SFN protects against LPS-induced acute liver injury. (A) Schematic diagram of the experimental design. (B,C) Plasma ALT and AST detection of control and LPS-treated mice with or without SFN pretreatment. (D,E) Representative images of HE staining and TUNEL staining in liver tissues from different groups (D) , and quantitative analysis of TUNEL positive cells (E) . Scale bar, 10 μm, 20x magnification. Five unique and representative fields from each sample were selected for further analysis. Data are presented as mean ± SEM of biologically independent samples. *P < 0.05, **P < 0.01. n = 6 per group. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Journal: Frontiers in Pharmacology

    Article Title: Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury

    doi: 10.3389/fphar.2025.1690067

    Figure Lengend Snippet: SFN protects against LPS-induced acute liver injury. (A) Schematic diagram of the experimental design. (B,C) Plasma ALT and AST detection of control and LPS-treated mice with or without SFN pretreatment. (D,E) Representative images of HE staining and TUNEL staining in liver tissues from different groups (D) , and quantitative analysis of TUNEL positive cells (E) . Scale bar, 10 μm, 20x magnification. Five unique and representative fields from each sample were selected for further analysis. Data are presented as mean ± SEM of biologically independent samples. *P < 0.05, **P < 0.01. n = 6 per group. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Article Snippet: And then, the mice were randomly divided into three groups ( n = 6 per group): Control, LPS (cat# L2630, Sigma, Saint Louis, United States) and LPS + SFN (cat# HY-13755, MCE, Shanghai, China).

    Techniques: Clinical Proteomics, Control, Staining, TUNEL Assay

    SFN alleviated LPS induced inflammatory response in liver. (A–C) Representative images of Ly6G and F4/80 staining of control and LPS-treated mice with or without SFN pretreatment (A) , and quantitative analysis (B,C) . Scale bar, 10 μm, 20x magnification. Five unique and representative fields from each sample were selected for further analysis. (D–G) mRNA expression of CXCL9, IL-6, MCP-1 and TNF-α in liver tissues from different groups. Data are presented as mean ± SEM of biologically independent samples. n = 6 per group. *P < 0.05, **P < 0.01. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Journal: Frontiers in Pharmacology

    Article Title: Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury

    doi: 10.3389/fphar.2025.1690067

    Figure Lengend Snippet: SFN alleviated LPS induced inflammatory response in liver. (A–C) Representative images of Ly6G and F4/80 staining of control and LPS-treated mice with or without SFN pretreatment (A) , and quantitative analysis (B,C) . Scale bar, 10 μm, 20x magnification. Five unique and representative fields from each sample were selected for further analysis. (D–G) mRNA expression of CXCL9, IL-6, MCP-1 and TNF-α in liver tissues from different groups. Data are presented as mean ± SEM of biologically independent samples. n = 6 per group. *P < 0.05, **P < 0.01. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Article Snippet: And then, the mice were randomly divided into three groups ( n = 6 per group): Control, LPS (cat# L2630, Sigma, Saint Louis, United States) and LPS + SFN (cat# HY-13755, MCE, Shanghai, China).

    Techniques: Staining, Control, Expressing

    SFN inhibited hepatocyte pyroptosis in ALI mice. (A–D) mRNA expression of NLRP3, Caspase 1, IL-1β and IL-18 in liver tissues from control and LPS-treated mice with or without SFN pretreatment. (E,F) Western blot analysis of GSDMD-N in different groups of mice (E) , and quantitative analysis (F) . (G,H) Plasma IL-1β and IL-18 detection in different groups. Data are presented as mean ± SEM of biologically independent samples. n = 6 per group. *P < 0.05, **P < 0.01. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Journal: Frontiers in Pharmacology

    Article Title: Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury

    doi: 10.3389/fphar.2025.1690067

    Figure Lengend Snippet: SFN inhibited hepatocyte pyroptosis in ALI mice. (A–D) mRNA expression of NLRP3, Caspase 1, IL-1β and IL-18 in liver tissues from control and LPS-treated mice with or without SFN pretreatment. (E,F) Western blot analysis of GSDMD-N in different groups of mice (E) , and quantitative analysis (F) . (G,H) Plasma IL-1β and IL-18 detection in different groups. Data are presented as mean ± SEM of biologically independent samples. n = 6 per group. *P < 0.05, **P < 0.01. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Article Snippet: And then, the mice were randomly divided into three groups ( n = 6 per group): Control, LPS (cat# L2630, Sigma, Saint Louis, United States) and LPS + SFN (cat# HY-13755, MCE, Shanghai, China).

    Techniques: Expressing, Control, Western Blot, Clinical Proteomics

    SFN activated Nrf2/HO-1 signaling pathway in liver. (A–C) Western blot analysis of Nrf2 and HO-1 in mice of control and LPS-treated mice with or without SFN pretreatment. (A) , and quantitative analysis (B,C) . (D,E) RT-qPCR analysis of Nrf2 and HO-1 in mice of control and LPS-treated mice with or without SFN pretreatment. (F) Measurement of SOD activity in the liver of different groups of mice. (G) Detection of MDA content in liver of different groups of mice. Data are presented as mean ± SEM of biologically independent samples. n = 6 per group. *P < 0.05, **P < 0.01. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Journal: Frontiers in Pharmacology

    Article Title: Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury

    doi: 10.3389/fphar.2025.1690067

    Figure Lengend Snippet: SFN activated Nrf2/HO-1 signaling pathway in liver. (A–C) Western blot analysis of Nrf2 and HO-1 in mice of control and LPS-treated mice with or without SFN pretreatment. (A) , and quantitative analysis (B,C) . (D,E) RT-qPCR analysis of Nrf2 and HO-1 in mice of control and LPS-treated mice with or without SFN pretreatment. (F) Measurement of SOD activity in the liver of different groups of mice. (G) Detection of MDA content in liver of different groups of mice. Data are presented as mean ± SEM of biologically independent samples. n = 6 per group. *P < 0.05, **P < 0.01. One-way ANOVA was used to analyze the data among multiple groups, followed by Tukey’s post hoc test.

    Article Snippet: And then, the mice were randomly divided into three groups ( n = 6 per group): Control, LPS (cat# L2630, Sigma, Saint Louis, United States) and LPS + SFN (cat# HY-13755, MCE, Shanghai, China).

    Techniques: Western Blot, Control, Quantitative RT-PCR, Activity Assay